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Season 1 Sep. 29, 2017
- Episode 1: Ejaculation
- Episode 2: Everybody Bleeds
- Episode 3: Am I Gay?
- Episode 4: Sleepover: A Harrowing Ordeal of Emotional...
- Episode 5: Girls Are Horny Too
- Episode 6: Pillow Talk
- Episode 7: Requiem for a Wet Dream
- Episode 8: The Head Push
- Episode 9: I Survived Jessi's Bat Mitzvah
- Episode 10: The Pornscape
Season 2 Oct. 05, 2018
- Episode 1: Am I Normal?
- Episode 2: What Is It About Boobs?
- Episode 3: The Shame Wizard
- Episode 4: Steve the Virgin
- Episode 5: The Planned Parenthood Show
- Episode 6: Drug Buddies
- Episode 7: Guy Town
- Episode 8: Dark Side of the Boob
- Episode 9: Smooch or Share
- Episode 10: The Department of Puberty
- Episode 11: Episod Special
Season 3 Feb. 08, 2019
Season 4 Dec. 04, 2020
Season 5 Nov. 05, 2021
- Episode 1: No Nut November
- Episode 2: The Shane Lizard Rises
- Episode 3: Lovebugs
- Episode 4: The Green-Eyed Monster
- Episode 5: Thanksgiving
- Episode 6: Best Friends Make the Best Lovers
- Episode 7: I F**king Hate You
- Episode 8: A Very Big Mouth Christmas
- Episode 9: Sugarbush
- Episode 10: Re-New Year's Eve
Season 6 Oct. 28, 2022
- Episode 1: The Hookup House
- Episode 2: Twenty Two and You
- Episode 3: Vagina Shame
- Episode 4: Rice Purity Test
- Episode 5: Andrew's Gonna Touch A Boob Tonight
- Episode 6: The Apple Brooch
- Episode 7: Dadda Dia!
- Episode 8: Asexual Healing
- Episode 9: The Parents Aren't Alright
- Episode 10: F**ked Up Friday
Season 7 Oct. 20, 2023
- Episode 1: Big Mouth’s Going to High School (But Not for Nine More Episodes)
- Episode 2: Epididymitis
- Episode 3: The Ambition Gremlin
- Episode 4: Day Tripping
- Episode 5: Graduation
- Episode 6: The International Show
- Episode 7: Get the F**k Outta My House
- Episode 8: The Bad Hookup
- Episode 9: Panic! At the Mall
Big Mouth Season 2 Episode 10
After traveling through a magic portal to puberty headquarters, Nick seeks out a new Hormone Monster and Jessi bonds with the Depression Kitty.